The Role of Aldosterone in the Development of Chronic Heart Failure and the Effectiveness of Mineralocorticoid Receptor Antagonists in its Treatment

Abstrak

Aldosterone is considered a steroid hormone and its prolonged increase in concentration affects blood pressure, causes complications and metabolic changes in diseases of the vessels, heart and kidneys. It is synthesized mainly from deoxycorticosterone under the influence of mitochondrial cytochrome R 450 aldosterone synthetase in the adrenal glomerular zone.

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