Effect of Atorvastatin Drug on The Liver Enzymes of Pregnant Mice and The Deformities of Their Fetus

Abstrak

Atorvastatin is used by many people around the world as a cholesterol-lowering medication in blood . And this study aimed to identify the physiological changes in the liver enzye of experimental mice . Where 30 mice were used, and they were divided into five groups, group A is the control consisting of 6 mice, Group B included 6 pregnant mice that were fed a high-fat diet, Group C included 6 pregnant mice dosed with concentration 20mg∕kg of atorvastatin, Group D included 6 pregnant mice dosed at a concentration of 40mg ∕kg , Group E included 6 pregnant mice dosed at a concentration of 80mg ∕kg ,Starting from the seventh day of pregnancy, the mice were dissected on the 18th day, and the concentrations of liver enzymes Alkaline phosphatase(ALP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), were measured. Where the results of the study showed an increase in liver enzymes in the blood serum. The fetus showed phenotypic changes from swelling of the body and face, shortness of the limbs, lack of phalanges, fusion of the phalanges, enlargement of the hind limb, long and hooked tail, short mandible, small size of the fetus, curvature of the trunk, and the appearance of fetus with one foot, And the most deformities were in the group that was dosed at a concentration of 80 mg.  From the foregoing, we conclude that atorvastatin has harmful effects on the physiological parameters of liver enzymes and fetus in pregnant mice.